Enhancement Risk Disease Cardiovascular in Children with Hypospadias
Keywords:
Hypospadias, Cardiovascular, PediatricAbstract
Hypospadias is a congenital disorder in boys due to low fetal androgen hormones. Hypospadias is one of the congenital disorders with the highest prevalence. Several studies have revealed the association of hypospadias with cardiovascular disease. There are still very few studies that summarize cardiovascular manifestations in pediatric hypospadias. Therefore, this study was designed to describe the cardiovascular risk in pediatric patients with hypospadias. Method : Journal searches were carried out through several research databases including Google Scholar, PubMed, and Sciencedirect . The keywords used were "hypospadias", "cardiovascular", and "pediatric". The results of the literature search were 1,543 journals with 20 journals meeting the criteria. Results and Discussion : Hypospadias is one of the second most common congenital abnormalities in men after testicular undescensus . Children born with hypospadias are proven to experience changes in vascular structure, namely increased carotid intima media thickness (CMIT) and are associated with hypertension. Hypospadias patients have impaired endothelial function, decreased vasorelaxation, and increased vasoreactivity. The underlying mechanism is a Rho kinase and ROS dependent process. Conclusion: Children with hypospadias have a higher risk of cardiovascular disease.
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A. K. Lucas-Herald Et Al., “Vascular Dysfunction And Increased Cardiovascular Risk In Hypospadias,” Eur. Heart J., Vol. 43, No. 19, Pp. 1832–1845, May 2022, Doi: 10.1093/Eurheartj/Ehac112.
Z. M. Younossi, G. Marchesini, H. Pinto-Cortez, And S. Petta, “Epidemiology Of Nonalcoholic Fatty Liver Disease And Nonalcoholic Steatohepatitis: Implications For Liver Transplantation,” Transplantation, Vol. 103, No. 1, Pp. 22–27, Jan. 2019, Doi: 10.1097/Tp.0000000000002484.
H. Geng, S. Cheng, X. Yang, And Y. Huang, “The Effect Of The Duckett Procedure On The Outcome And Prognosis Of Children With Suburethral Cleft,” Contrast Media Mol. Imaging, Vol. 2022, Pp. 1–8, Jun. 2022, Doi: 10.1155/2022/7444104.
X.-Q. Shi, S.-L. Guo, W. Zheng, B.-S. Zhang, J. Wang, And B. Yang, “Effect Of Preventive Nursing On Male Children With Hypospadias In Preventing Postoperative Complications,” J. Coll. Physicians Surg. Jcpsp, Vol. 33, No. 10, Pp. 1153–1158, 2023, Doi: 10.29271/Jcpsp.2023.10.1153.
M. A. Richard Et Al., “Prevalence And Clustering Of Congenital Heart Defects Among Boys With Hypospadias,” Jama Netw. Open, Vol. 5, No. 7, Pp. E2224152–E2224152, 2022.
S. A. Mohamed, “Effect Of Pre-Designed Instructions For Mothers Of Children With Hypospadias On Postoperative Complications,” 2019.
K. O. Rove, J. C. Edney, And M. A. Brockel, “Enhanced Recovery After Surgery In Children: Promising, Evidence‐Based Multidisciplinary Care,” Pediatr. Anesth., Vol. 28, No. 6, Pp. 482–492, Jun. 2018, Doi: 10.1111/Pan.13380.
S. Poon Et Al., “Association Of In Utero Exposure To Polybrominated Diphenyl Ethers With The Risk Of Hypospadias,” Jama Pediatr., Vol. 172, No. 9, P. 851, Sep. 2018, Doi: 10.1001/Jamapediatrics.2018.1492.
A. M. Tache, L. D. Dinu, And E. Vamanu, “Novel Insights On Plant Extracts To Prevent And Treat Recurrent Urinary Tract Infections,” Appl. Sci., Vol. 12, No. 5, P. 2635, 2022, Doi: Https://Doi.Org/10.3390/App12052635.
T. Angerpointner, “Hypospadias - Genetics, Epidemiology And Other Possible Aetiological Influences,” Eur. J. Pediatr. Surg., Vol. 39, No. 02, Pp. 112–118, Mar. 2008, Doi: 10.1055/S-2008-1044188.
K. Li, X. Zhang, G. Yan, W. Zheng, And Y. Zou, “Prenatal Diagnosis And Classification Of Fetal Hypospadias: The Role And Value Of Magnetic Resonance Imaging,” J. Magn. Reson. Imaging, Vol. 53, No. 6, Pp. 1862–1870, Jun. 2021, Doi: 10.1002/Jmri.27519.
X. He Et Al., “Reduced Anogenital Distance, Hematuria And Left Renal Hypoplasia In A Patient With 13q33.1–34 Deletion: Case Report And Literature Review,” Bmc Pediatr., Vol. 20, No. 1, P. 327, Dec. 2020, Doi: 10.1186/S12887-020-02205-7.
H. Zhang Et Al., “Alternate-Day Fasting Alleviates Diabetes-Induced Glycolipid Metabolism Disorders: Roles Of Fgf21 And Bile Acids,” J. Nutr. Biochem., Vol. 83, P. 108403, Sep. 2020, Doi: 10.1016/J.Jnutbio.2020.108403.
S. Swain And S. Pradhan, “Impact Of Laryngopharyngeal Reflux On Professional Singers,” Apollo Med., Vol. 16, No. 4, P. 220, 2019, Doi: 10.4103/Am.Am_24_19.
A. Mostafa Abd El-Moniem Ali, A. Mohamed Ahmed, And M. Shams El-Din Abd El-Haliem, “Tympanometric Changes In Gastro Esophageal Reflux Disease Patients,” Al-Azhar Med. J., Vol. 50, No. 2, Pp. 1209–1216, Apr. 2021, Doi: 10.21608/Amj.2021.158467.
Y. Zhou Et Al., “Epidemiology Of Birth Defects Based On A Birth Defect Surveillance System In Southern Jiangsu, China, 2014–2018,” J. Matern. Neonatal Med., Vol. 35, No. 4, Pp. 745–751, Feb. 2022, Doi: 10.1080/14767058.2020.1731459.
S. Gaitonde, R. D. Malik, And P. E. Zimmern, “Financial Burden Of Recurrent Urinary Tract Infections In Women: A Time-Driven Activity-Based Cost Analysis,” Urology, Vol. 128, Pp. 47–54, 2019, Doi: Https://Doi.Org/10.1016/J.Urology.2019.01.031.
D. E. Nassau, K. Y. Chu, R. Blachman-Braun, M. Castellan, And R. Ramasamy, “The Pediatric Patient And Future Fertility: Optimizing Long-Term Male Reproductive Health Outcomes,” Fertil. Steril., Vol. 113, No. 3, Pp. 489–499, Mar. 2020, Doi: 10.1016/J.Fertnstert.2020.01.003.
J. R. Lechien Et Al., “The Development Of New Clinical Instruments In Laryngopharyngeal Reflux Disease: The International Project Of Young Otolaryngologists Of The International Federation Of Oto-Rhino-Laryngological Societies,” Eur. Ann. Otorhinolaryngol. Head Neck Dis., Vol. 135, No. 5, Pp. S85–S91, Sep. 2018, Doi: 10.1016/J.Anorl.2018.05.013.
F. C. G. B. Santos Et Al., “Surgical Treatment For Congenital Heart Defects In Down Syndrome Patients,” Brazilian J. Cardiovasc. Surg., Vol. 34, Pp. 1–7, 2019.
S. Handayani And U. Aiman, “Analisis Kejadian Hiperemesis Gravidarum (Heg) Berdasarkan Karakteristiknya,” Babul Ilmi J. Ilm. Multi Sci. Kesehat., Vol. 9, No. 1, 2018, Doi: Https://Doi.Org/10.36729/Bi.V9i1.123.
C. H. Scott And I. E. Amarillo, “Identification Of Small Regions Of Overlap From Copy Number Variable Regions In Patients With Hypospadias,” Int. J. Mol. Sci., Vol. 23, No. 8, P. 4246, Apr. 2022, Doi: 10.3390/Ijms23084246.
A. Chakrawarty Et Al., “Psycho-Social And Behavioral Impact Of Covid-19 On Middle-Aged And Elderly Individuals: A Qualitative Study,” J. Educ. Health Promot., Vol. 10, 2021, Doi: Https://Doi.Org/10.4103%2fjehp.Jehp_1458_20.
M. L. Russell, A. H. Carr, And K. Kieran, “Using Mind Mapping In Family Meetings To Support Shared Decision Making With Pediatric And Geriatric Patients,” Patient - Patient-Centered Outcomes Res., Vol. 13, No. 6, Pp. 709–717, Dec. 2020, Doi: 10.1007/S40271-020-00447-2.
E. C. De Andrade Et Al., “Echocardiographic Evaluation Of Left Ventricular Mass Index In Children With Hypospadias After Hormonal Stimulation With Topical Testosterone: A Randomized Controlled Trial,” J. Pediatr. Urol., Vol. 13, No. 4, Pp. 352.E1-352.E7, Aug. 2017, Doi: 10.1016/J.Jpurol.2017.03.019.
H. S. Janjua, S. K. Lam, V. Gupta, And S. Krishna, “Congenital Anomalies Of The Kidneys, Collecting System, Bladder, And Urethra,” Pediatr. Rev., Vol. 40, No. 12, Pp. 619–626, Dec. 2019, Doi: 10.1542/Pir.2018-0242.
S. B. Bauer, M. J. Bull, And A. B. Retik, “Hypospadias: A Familial Study,” J. Urol., Vol. 121, No. 4, Pp. 474–477, Apr. 2020, Doi: 10.1016/S0022-5347(17)56832-9.
M. Hardiah, H. Nabawiyah, And K. Pibriyanti, “Correlation Between Knowledge And Attitudes To The Behavior Of Personal Hygiene Food Handlers In Nutrient Department,” Sport Nutr. J., Vol. 2, No. 1, Pp. 17–24, Jul. 2020, Doi: 10.15294/Spnj.V2i1.37957.
G. Sun, Z.-M. Xu, J.-F. Liang, L. Li, And D.-X. Tang, “Twelve-Year Prevalence Of Common Neonatal Congenital Malformations In Zhejiang Province, China,” World J. Pediatr., Vol. 7, No. 4, Pp. 331–336, Nov. 2011, Doi: 10.1007/S12519-011-0328-Y.
M. E. Pierpont Et Al., “Genetic Basis For Congenital Heart Disease: Revisited: A Scientific Statement From The American Heart Association,” Circulation, Vol. 138, No. 21, Pp. E653–E711, Nov. 2018, Doi: 10.1161/Cir.0000000000000606.
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