The Identification of Phytocompounds from Limonia acidissima L. Fruit: A Short Report and Updated Review – Focusing on Antihyperuricemic and Antiarthritic Activities
Keywords:
Antioxidant, phytoconstituents, inflammation, Limonia acidissima, uric acidAbstract
The side effects of using anti-gout and anti-inflammatory drugs in patients with hyperuricemia and gouty arthritis are the reason to get alternative, safer herbal medicines. To answer the call from the Indonesian government to explore the natural product potential as treatment modalities against various diseases, we performed an investigation on Limonia acidissima L. fruit. Extraction of the Limonia acidissima L. fruit was carried out by means of maceration using different solvents (n-hexane, ethyl acetate, ethanol, and methanol), performed sequentially. Phytoconstituents of each extract were further determined by using Gas Chromatography – Mass Spectroscopy (GC-MS). The results revealed that L. acidissima fruit is rich with fatty acids including oleic acid, n-hexadecanoic acid, palmitoleic acid, and octadecanoic acid. Several important plant sterols, such as sitosterol, stigmasterol, ergost-5-en-3-ol, (3beta.), were also found in the extract. Updated literature review confirmed the potential of Limonia acidissima L. fruit application as phytomedicine. To conclude, we recommend further investigation on the L. acidissima fruit potentials as antihyperuricemic and antiarthritic therapies
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G. Cabău, T. O. Crișan, V. Klück, R. A. Popp, and L. A. B. Joosten, “Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia,” Immunol. Rev., vol. 294, no. 1, pp. 92–105, 2020, doi: 10.1111/imr.12833.
I. Ikhsan, R. Idroes, A. Azharuddin, R. Nasution, R. Yusnaini, and M. Iqhrammullah, “Fatty Acid-Rich Extract from Holothuria atra for Hyperuricemia via Expressions Modulation of GLUT9a and GLUT9b in Rat Model,” Molecules, vol. 28, no. 10, May 2023, doi: 10.3390/molecules28103981.
P. Kemala et al., “Green Synthesis and Antimicrobial Activities of Silver Nanoparticles Using Calotropis gigantea from Ie Seu-Um Geothermal Area, Aceh Province, Indonesia,” Molecules, vol. 27, no. 16. 2022. doi: 10.3390/molecules27165310.
D. Harahap et al., “Antibacterial activities of seven ethnomedicinal plants from family Annonaceae,” J. Adv. Pharm. Technol. Res., vol. 13, no. 3, p. 148, 2022.
N. Andalia, M. N. Salim, N. Saidi, M. Ridhwan, M. Iqhrammullah, and U. Balqis, “Molecular Docking Reveals Phytoconstituents of the Methanol Extract from Muntingia calabura as Promising α-Glucosidase Inhibitors Muntingia calabura as Promising-Glucosidase Inhibitors,” Karbala Int. J. Mod. Sci., vol. 8, no. 3, pp. 330–338, 2022.
D. Vishakha, Bhagwan Bagul Sonal, S. Disha, and D. Sneha, “Wood Apple (Limonia Acidissima L.) : A Multipurpose Herb In Cosmetics,” Int. J. Sci. Eng. Dev. Res., vol. 4, no. 7, pp. 172–181, 2019, [Online]. Available: http://www.ijsdr.org/papers/IJSDR1907029.pdf
V. H. Jayashree and R. Londonkar, “Comparative phytochemical studies and antimicrobial potential of fruit extracts of Feronia limonia Linn,” Int. J. Pharm. Pharm. Sci., vol. 6, no. 1, pp. 731–734, 2014.
G. D. Reddy, K. N. Rani, G. V. N. Kumar, P. Elankani, and M. P. Kumar, “a Comprehensive Review on Thetran Vidhai Kudineer: a Siddha Polyherbal Formulation,” Int. Res. J. Pharm., vol. 10, no. 3, pp. 42–48, 2019, doi: 10.7897/2230-8407.100376.
S. Lamani, K. A. Anu-Appaiah, H. N. Murthy, Y. H. Dewir, and H. Z. Rihan, “Fatty acid profile, tocopherol content of seed oil, and nutritional analysis of seed cake of wood apple (Limonia acidissima l.), an underutilized fruit-yielding tree species,” Horticulturae, vol. 7, no. 9, 2021, doi: 10.3390/horticulturae7090275.
M. W. Lim, M. K. Aroua, and L. T. Gew, “Thanaka (H. crenulata, n. crenulata, l. acidissima l.): A systematic review of its chemical, biological properties and cosmeceutical applications,” Cosmetics, vol. 8, no. 3, 2021, doi: 10.3390/cosmetics8030068.
R. Yusnaini et al., “Near-infrared spectroscopy (NIRS) as an integrated approach for rapid classification and bioactive quality evaluation of intact Feronia limoni,” IOP Conf. Ser. Earth Environ. Sci., vol. 667, no. 1, 2021, doi: 10.1088/1755-1315/667/1/012028.
G. Williamson, C. D. Kay, and A. Crozier, “The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective,” Compr. Rev. Food Sci. Food Saf., vol. 17, no. 5, pp. 1054–1112, 2018, doi: 10.1111/1541-4337.12351.
A. Masyita et al., “Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives,” Food Chem. X, vol. 13, no. October 2021, p. 100217, 2022, doi: 10.1016/j.fochx.2022.100217.
W. M. Oo, M. M. Khine, and W. M. Oo, “PHARMACOLOGICAL PROPERTIES OF FERONIA LIMONIA FRUIT PULP – A REVIEW Win Min Oo, Myat Mon Khine,” vol. 7, no. 04, 2017.
G. Libório et al., “Phytochemical profile , anti-inflammatory , antimutagenic and antioxidant properties of Acrocomia aculeata ( Jacq .) Lodd . pulp oil,” vol. 2061, no. 4, pp. 963–971, 2020.
M. Abubakar and R. Majinda, “GC-MS Analysis and Preliminary Antimicrobial Activity of Albizia adianthifolia (Schumach) and Pterocarpus angolensis (DC),” Medicines, vol. 3, no. 1, p. 3, 2016, doi: 10.3390/medicines3010003.
A. Jenecius, F. Uthayakumari, and V. Mohan, “Gc-Ms Determination of Bioactive Components of Sauropus Bacciformis Blume (Euphorbiaceae),” J. Curr. Chem. Pharm. Sci., vol. 2, no. January 2012, pp. 347–358, 2012.
Y. Andriana, T. D. Xuan, T. N. Quy, T. N. Minh, T. M. Van, and T. D. Viet, “Antihyperuricemia, antioxidant, and antibacterial activities of tridax procumbens L.,” Foods, vol. 8, no. 1, pp. 1–12, 2019, doi: 10.3390/foods8010021.
X. Ling and W. Bochu, “A review of phytotherapy of gout: Perspective of new pharmacological treatments,” Pharmazie, vol. 69, no. 4, pp. 243–256, 2014, doi: 10.1691/ph.2014.3642.
Z. S. Ferraz-Filha, M. C. de P. Michel Araújo, F. C. Ferrari, I. P. A. R. Dutra, and D. A. Saúde-Guimarães, “Tabebuia roseoalba: In Vivo Hypouricemic and Anti-inflammatory Effects of Its Ethanolic Extract and Constituents,” Planta Med., vol. 82, no. 16, pp. 1395–1402, 2016, doi: 10.1055/s-0042-105878.
S. Ponnuraj, D. Jaganathan, M. Kanagarajan, T. Priya, and D. Deivamarudachalam, “Spectroscopic analysis and antibacterial efficacy of bioactive compounds from Limonia acidissima L. Fruit extract against clinical pathogens,” Int. J. Pharm. Pharm. Sci., vol. 7, no. 3, pp. 383–389, 2015.
G. Tripathy and D. Pradhan, “Estimation of immunomodulatory activity of Limonia acidissima Linn.,” Asian J. Pharm. Clin. Res., vol. 7, no. 1, pp. 219–221, 2014.
B. N. Patil and T. C. Taranath, “Limonia acidissima L. leaf mediated synthesis of zinc oxide nanoparticles: A potent tool against Mycobacterium tuberculosis,” Asian African Soc. Mycobacteriology, 2016, doi: 10.1016/j.ijmyco.2016.03.004.
P. B. Rakhunde, S. Saher, and S. A. Ali, “Neuroprotective effect of Feronia limonia on ischemia reperfusion induced brain injury in rats,” Indian J. Pharmacol., vol. 46, no. 6, pp. 617–621, 2014, doi: 10.4103/0253-7613.144920.
R. Dhanapal, J. Vijaya Ratna, I. Sarathchandran, and M. Gupta, “Reversible antispermatogenic and antisteroidogenic activities of Feronia limonia fruit pulp in adult male rats,” Asian Pac. J. Trop. Biomed., vol. 2, no. 9, pp. 684–690, 2012, doi: 10.1016/S2221-1691(12)60210-X.
M. Jain, R. Kapadia, R. N. Jadeja, M. C. Thounaojam, R. V. Devkar, and S. H. Mishra, “Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. linn leaf extracts,” EXCLI J., vol. 11, pp. 250–259, 2012, doi: 10.17877/DE290R-5762.
M. Jain, R. Kapadia, R. N. Jadeja, M. C. Thounaojam, R. V. Devkar, and S. H. Mishra, “Hepatoprotective activity of Feronia limonia root,” J. Pharm. Pharmacol., vol. 64, no. 6, pp. 888–896, 2012, doi: 10.1111/j.2042-7158.2012.01481.x.
E. K. Kilari, S. Putta, R. Koratana, N. R. Nagireddy, and A. A. Qureshi, “Inhibitory effects of methonolic pericarp extract of Feronia limonia on in vitro protein glycoxidation,” International Journal of Pharmacology, vol. 11, no. 1. pp. 35–42, 2015. doi: 10.3923/ijp.2015.35.42.
H. Wang, L. Cheng, D. Lin, Z. Ma, and X. Deng, “Lemon fruits lower the blood uric acid levels in humans and mice,” Sci. Hortic. (Amsterdam)., vol. 220, pp. 4–10, 2017, doi: 10.1016/j.scienta.2017.03.023.
S. J. White, E. L. Carran, A. N. Reynolds, J. J. Haszard, and B. J. Venn, “The effects of apples and apple juice on acute plasma uric acid concentration: A randomized controlled trial,” Am. J. Clin. Nutr., vol. 107, no. 2, pp. 165–172, 2018, doi: 10.1093/ajcn/nqx059.
Y. Barghouthy and B. K. Somani, “Role of Citrus Fruit Juices in Prevention of Kidney Stone Disease (KSD): A Narrative Review,” Evidentia, vol. 18, p. e12814, 2021, doi: 10.1371/journal.pmed1000097.
C. V. Odvina, “Comparative value of orange juice versus lemonade in reducing stone-forming risk.,” Clin. J. Am. Soc. Nephrol., vol. 1, no. 6, pp. 1269–1274, 2006, doi: 10.2215/CJN.00800306.
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