The Effect of Telang Flower Extract (Clitoria Ternatea) on Reducing Total Cholesterol Levels in Male Wistar Rats (Rattus Norvegicus) with Obesity

https://doi.org/10.55299/ijphe.v3i2.755

Authors

  • Aprillia Sri Haryati Master Study Program in Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Prima Indonesia University, Medan
  • Claudia Tanamal Master Study Program in Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Prima Indonesia University, Medan
  • Fransiskus Aryo Pratomo Master Study Program in Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, Prima Indonesia University, Medan

Keywords:

Telang Flower, Cholesterol Levels, Obesity

Abstract

Several health problems can arise from obesity, including an increased risk of diabetes mellitus, heart disease, high blood pressure, and high cholesterol. High cholesterol levels are associated with obesity, which is a health risk in and of itself. Achieving excellent health requires careful monitoring of cholesterol levels, and one way to do this is to eat foods rich in antioxidants. Specifically, this study used a laboratory experimental design, a true of experimental quantitative research. The research used twenty-four male Wistar rats (Rattus norvegicus). This study set out to compare the pre-and post-administration of Telang flower extract (Clitoria ternatea) to total cholesterol levels in the blood of rats (Rattus norvegicus). The tests were administered for homogeneity, one-way ANOVA, and normality. After that, SPSS was used to examine the study data. Researchers observed that compared to other methods, a 600mg/KgBW dose of butterfly pea flower extract (Clitoria ternatea) significantly reduced total cholesterol levels in obese male Wistar rats (Rattus norvegicus) from 65.06mg/dl to 37.46mg/dl. The study found that the phytochemical content of Telang flowers helped obese people lower their cholesterol levels.

Downloads

Download data is not yet available.

References

B. Caballero, “Humans against Obesity: Who Will Win?,” Adv. Nutr., vol. 10, pp. S4–S9, 2019, doi: 10.1093/advances/nmy055.

R. Yudin et al., “Risk of Dyslipidemia in Obese Young Adult Subjects as Measured by Various Obesity Indices,” J. Endocrinol. Metab., vol. 12, no. 3, pp. 102–106, 2022, doi: 10.14740/jem819.

G. Muscogiuri et al., “The management of very-low-calorie ketogenic diet in obesity outpatient clinic: A practical guide,” J. Transl. Med., vol. 17, no. 1, pp. 1–9, 2019, doi: 10.1186/s12967-019-2104-z.

J. M. Oppert et al., “Exercise training in the management of overweight and obesity in adults: Synthesis of the evidence and recommendations from the European Association for the Study of Obesity Physical Activity Working Group,” Obes. Rev., vol. 22, no. S4, pp. 1–12, 2021, doi: 10.1111/obr.13273.

IDF Committee, International Diabetes Federation Atlas, 9th ed. Online Edition: Pfizer - MSD - Alliance - Lilly - Novo Nordisk, 2019. doi: 10.1016/S0140-6736(55)92135-8.

A. Kerkadi et al., “The relationship between lifestyle factors and obesity indices among adolescents in Qatar,” Int. J. Environ. Res. Public Health, vol. 16, no. 22, pp. 1–15, 2019, doi: 10.3390/ijerph16224428.

D. Albuquerque, C. Nóbrega, L. Manco, and C. Padez, “The contribution of genetics and environment to obesity,” Br. Med. Bull., vol. 123, no. 1, pp. 159–173, 2017, doi: 10.1093/bmb/ldx022.

M. Sonal Sekhar, B. S. Reddy, S. J. Kurian, M. Rao, and S. Marupuru, “Physiological role of cholesterol in human body,” in Dietary Sugar, Salt and Fat in Human Health, H. G. Preuss and D. Bagchi, Eds., Academic Press, 2020, pp. 453–481. doi: 10.1016/B978-0-12-816918-6.00021-4.

H. Oguro, “The roles of cholesterol and its metabolites in normal and malignant hematopoiesis,” Front. Endocrinol. (Lausanne)., vol. 10, no. APR, pp. 1–15, 2019, doi: 10.3389/fendo.2019.00204.

K. R. Feingold, “Lipid and Lipoprotein Metabolism,” Endocrinol. Metab. Clin. North Am., vol. 51, no. 3, pp. 437–458, 2022, doi: 10.1016/j.ecl.2022.02.008.

H. H. Wang, G. Garruti, M. Liu, P. Portincasa, and D. Q. H. Wang, “Cholesterol and lipoprotein metabolism and atherosclerosis: Recent advances in reverse cholesterol transport,” Ann. Hepatol., vol. 16, pp. s27–s42, 2017, doi: 10.5604/01.3001.0010.5495.

F. M. Sacks et al., “Dietary fats and cardiovascular disease: A presidential advisory from the American Heart Association,” Circulation, vol. 136, no. 3, pp. e1–e23, 2017, doi: 10.1161/CIR.0000000000000510.

R. R. Multisona, S. Shirodkar, M. Arnold, and A. Gramza-Michalowska, “Clitoria ternatea Flower and Its Bioactive Compounds: Potential Use as Microencapsulated Ingredient for Functional Foods,” Appl. Sci., vol. 13, no. 4, 2023, doi: 10.3390/app13042134.

S. Dhanasekaran, A. Rajesh, T. Mathimani, S. Melvin Samuel, R. Shanmuganathan, and K. Brindhadevi, “Efficacy of crude extracts of Clitoria ternatea for antibacterial activity against gram negative bacterium (Proteus mirabilis),” Biocatal. Agric. Biotechnol., vol. 21, no. August, p. 101328, 2019, doi: 10.1016/j.bcab.2019.101328.

P. K. Mukherjee, V. Kumar, N. S. Kumar, and M. Heinrich, “The Ayurvedic medicine Clitoria ternatea-From traditional use to scientific assessment,” J. Ethnopharmacol., vol. 120, no. 3, pp. 291–301, 2008, doi: 10.1016/j.jep.2008.09.009.

M. B. Lijon, N. S. Meghla, E. Jahedi, M. A. Rahman, and I. Hossain, “Phytochemistry and Pharmacological Activities of Clitoria ternatea,” Int. J. Nat. Soc. Sci., vol. 4, no. 1, pp. 01–10, 2017, [Online]. Available: www.ijnss.org

S. Ab Rashid et al., “Anthocyanin Microcapsule from Clitoria ternatea: Potential Bio-preservative and Blue Colorant for Baked Food Products,” Arab. J. Sci. Eng., vol. 46, no. 1, pp. 65–72, 2021, doi: 10.1007/s13369-020-04716-y.

N. Upwar, R. Patel, N. Waseem, and N. K. Mahobia, “Evaluation of antidiarrhoeal activity of the root of Clitoria ternatea Linn,” Int. J. Pharm. Sci. Rev. Res., vol. 5, no. 1, pp. 131–134, 2010.

D. S. K. Sarma, D. Kumar, C. Yamini, C. Santhalahari, C. Lahari, and G. C. Kumar, “Review on Clitoria Ternata,” Int. J. Pharm. Sci. Med., vol. 8, no. 9, pp. 43–58, 2023, doi: 10.47760/ijpsm.2023.v08i09.004.

C. Li et al., “Phytochemical Properties and In Vitro Biological Activities of Phenolic Compounds from Flower of Clitoria ternatea L.,” Molecules, vol. 27, no. 19, 2022, doi: 10.3390/molecules27196336.

S. Notoatmodjo, Metodologi Penelitian Kesehatan, 3rd ed. Jakarta: Rineka Cipta, 2022.

B. Suwarno and A. Nugroho, Kumpulan Variabel-Variabel Penelitian Manajemen Pemasaran (Definisi & Artikel Publikasi), 1st ed. Bogor: Halaman Moeka Publishing, 2023.

I. Ghozali, Aplikasi Analisis Multivariate dengan Program IBM SPSS 25. Semarang, 2018.

S.-I. Lee et al., “Anti-obesity Effect of Monascus pilosus Mycelial Extract in High Fat Diet-induced Obese Rats,” J. Appl. Biol. Chem., vol. 54, no. 3, pp. 197–205, 2011, doi: 10.3839/jabc.2011.033.

J. B. Smith and S. Mangkoewidjojo, Pemeliharaan, Pembiakan dan Penggunaan Hewan Percobaan Di Daerah Tropis. Jakarta: UI-Press, 1988.

Sugiyono, Statistika untuk Penelitian, 3rd ed. Bandung: Alfabeta, 2019.

Sugiyono, Metode penelitian kuantitatif, kualitatif dan kombinasi (mixed methods), 2nd ed. Bandung: Alfabeta, 2018.

R. Setyawati and M. Lasroha, “Overview of HDL, LDL, Triglycerides, and Total Cholesterol in Obese Patients,” Adv. Heal. Sci. Res., vol. 39, no. SeSICNiMPH, pp. 12–14, 2021.

A. Di Ciaula et al., “Bile acid physiology,” Ann. Hepatol., vol. 16, pp. s4–s14, 2017, doi: 10.5604/01.3001.0010.5493.

T. Huff, B. Boyd, and I. Jialal, Physiology, Cholesterol. Creighton University School of Medicine: StatPearls Publishing, Treasure Island (FL), 2023. [Online]. Available: http://europepmc.org/abstract/MED/29262185

Y. Arifah, S. Sunarti, and R. Prabandari, “Efek Bunga Telang (Clitoria ternatea L.) Terhadap Kolesterol Total, LDL, HDL Pada Tikus (Rattus Norvegicus ),” J. Syifa Sci. Clin. Res., vol. 4, no. 1, pp. 18–31, 2022, doi: 10.37311/jsscr.v4i1.13493.

E. Purnomo, “The Effect of Drinking Telang Flower Tea on Weight Reduction And Cholesterol,” Medikora, vol. 22, no. 2, pp. 22–32, 2023, doi: 10.21831/medikora.v22i2.66493.

Published

2024-02-09

How to Cite

Haryati, A. S., Tanamal, C., & Pratomo, F. A. (2024). The Effect of Telang Flower Extract (Clitoria Ternatea) on Reducing Total Cholesterol Levels in Male Wistar Rats (Rattus Norvegicus) with Obesity. International Journal of Public Health Excellence (IJPHE), 3(2), 589–596. https://doi.org/10.55299/ijphe.v3i2.755