Vitamin K Supplementation for Reducing Cardiovascular Events in End-Stage Chronic Kidney Disease: A Systematic Review

https://doi.org/10.55299/ijphe.v4i1.919

Authors

  • Kevin Liora RSUD Bajawa, Ngada, Nusa Tenggara Timur, Indonesia
  • Putri Dhiya Prameswari Wiyono Fakultas Kedokteran, Universitas Tarumanagara, Indonesia
  • Ananda Putra Fakultas Kedokteran, Universitas Tarumanagara, Indonesia
  • Devin Alexander Rumah sakit Harapan Kota Magelang, Indonesia
  • Afif Ramadhan FKKMK, Universitas Gadjah Mada, Indonesia
  • Anissya Rima Oktavia Fakultas Kedokteran, Universitas Tarumanagara, Indonesia
  • Olivia Larissa Fakultas Kedokteran, Universitas Tarumanagara, Indonesia
  • Fajar Prianto Nugroho Pendidikan Dokter, Universitas Muhammadiyah Yogyakarta, Indonesia
  • Teddy Tjahyanto Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

Keywords:

Vitamin K Supplementation, Cardiovascular, End-stage Chronic Kidney Disease

Abstract

This study was conducted to analyze the hSIL of Vitamin K Supplementation in Reducing Cardiovascular Events in End-Stage Chronic Kidney Disease: A Systematic Review. Cardiovascular disease (CVD) is the leading source of morbidity and mortality worldwide, and chronic kidney disease (CKD) is a major contributor to this matter. Kidney disease is estimated to affect  over 850 million people worldwide. The present systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We searched studies from electronic databases (PubMed Central, ScienceDirect, PLoS One, Google Scholar, Nature). Studies were considered eligible if they met the following criteria : (1) the study is a randomized controlled trial (RCT), (2) the study was published in the last 5 years (2018– 2022), (3) the study participants were adult patients with kidney disease from stage III to end-stage who were given vitamin K supplementation, (4) the study reported coronary artery calcium scores pre- and post- vitamin K supplementation, (5) the study was published in English. Risk of bias of each study was evaluated using Cochrane Risk of Bias (RoB) 2 tool. Data were descriptively examined and narratively reported. In conclusion, our results do not suggest that vitamin K supplementation may affect vascular calcification as measured by the CAC score.  Up till now there is no treatment to reverse vascular calcification in ESKD patients. The current clinical practice should focus on prevention and retardation of its progression. 

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Author Biographies

Putri Dhiya Prameswari Wiyono, Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

Ananda Putra, Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

Devin Alexander, Rumah sakit Harapan Kota Magelang, Indonesia

Rumah sakit Harapan Kota Magelang, Indonesia

Afif Ramadhan, FKKMK, Universitas Gadjah Mada, Indonesia

FKKMK, Universitas Gadjah Mada, Indonesia

Anissya Rima Oktavia, Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

Olivia Larissa, Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

Fajar Prianto Nugroho, Pendidikan Dokter, Universitas Muhammadiyah Yogyakarta, Indonesia

Pendidikan Dokter, Universitas Muhammadiyah Yogyakarta, Indonesia

Teddy Tjahyanto, Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

Fakultas Kedokteran, Universitas Tarumanagara, Indonesia

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Published

2024-07-07

How to Cite

Liora, K., Wiyono, P. D. P., Putra, A., Alexander, D., Ramadhan, A., Oktavia, A. R., Larissa, O., Nugroho, F. P., & Tjahyanto, T. (2024). Vitamin K Supplementation for Reducing Cardiovascular Events in End-Stage Chronic Kidney Disease: A Systematic Review. International Journal of Public Health Excellence (IJPHE), 4(1), 037–043. https://doi.org/10.55299/ijphe.v4i1.919